Paper Title:
Controlled Release of Growth Factor Using Poly(N-Isopropyl Acrylamide)Copolymer Hydrogels with Different Volume Phase Transition Temperatures
  Abstract

The release behavior of the basic fibroblast growth factor (bFGF) from copolymer hydrogels of N-isopropyl acrylamide (NIPAAm) and sodium methacrylate (SMA) was investigated in relation to the volume phase transition temperatures, which was increased by the incorporation of SMA. In the case of the copolymer hydrogels, a higher volume phase transition temperature was obtained when poly(ethylene glycol) diacrylate (PEGDA) was used as the crosslinking agent, suggesting that the chain length of the crosslinking agent has a significant affect on the volume phase transition temperature of a P(NIPAAm-co-SMA) hydrogel. The concentration of bFGF released from the hydrogels with PEGDA increased relative to the water content, thereby showing a dependence on the volume phase transition temperature. Hence, the release behavior of bFGF from the PNIPAAm and P(NIPAAm-co-SMA) hydrogels was found to be affected by the volume phase transition temperature, which can be easily controlled by changing the comonomer, monomer feed ratio, and crosslinking agent.

  Info
Periodical
Key Engineering Materials (Volumes 277-279)
Edited by
Kwang Hwa Chung, Yong Hyeon Shin, Sue-Nie Park, Hyun Sook Cho, Soon-Ae Yoo, Byung Joo Min, Hyo-Suk Lim and Kyung Hwa Yoo
Pages
77-81
DOI
10.4028/www.scientific.net/KEM.277-279.77
Citation
Y. A. Han, J. O. Lim, J. H. Choi, B. C. Ji, "Controlled Release of Growth Factor Using Poly(N-Isopropyl Acrylamide)Copolymer Hydrogels with Different Volume Phase Transition Temperatures ", Key Engineering Materials, Vols. 277-279, pp. 77-81, 2005
Online since
January 2005
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$32.00
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