Paper Title:

Using X-Ray Micro-CT Imaging to Monitor Dissolution of Macroporous Bioactive Glass Scaffolds

Periodical Key Engineering Materials (Volumes 284 - 286)
Main Theme Bioceramics 17
Edited by Panjian Li, Kai Zhang and Clifford W. Colwell, Jr.
Pages 493-496
DOI 10.4028/
Citation Julian R. Jones et al., 2005, Key Engineering Materials, 284-286, 493
Online since April 2005
Authors Julian R. Jones, Georgina E. Milroy, Ruth Cameron, William Bonfield, Larry L. Hench
Keywords Bioactive Glass, Dissolution, Macropores, Scaffold, X-Ray Micro-Computer Tomography
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Bioactive glass scaffolds with interconnected macroporous networks have been developed by foaming sol-gel derived bioactive glass of the 70S30C (70 mol% SiO2, 30 mol% CaO) composition. The effect of sintering temperature on the dissolution of the scaffolds in simulated body fluid (SBF) was investigated in 3D using x-ray micro-computer tomography (micro CT) and inductive coupled plasma (ICP) analysis. Micro-CT is non-destructive and allows observation of specific parts of the scaffold at various stages of degradation. However, data analysis is complex at present. Percentage porosity data obtained by micro-CT was compared to physical data and pore size distributions obtained from mercury intrusion porosimetry were compared to the interconnected pore diameters observed from the micro CT images.