Effect of Calcium Phosphate Addition to Alginate Microspheres: Modulation of Enzyme Release Kinetics and Improvement of Cell Adhesion |
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| Journal | Key Engineering Materials (Volumes 284 - 286) |
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| Volume | Bioceramics 17 |
| Edited by | Panjian Li, Kai Zhang and Clifford W. Colwell, Jr. |
| Pages | 689-692 |
| DOI | 10.4028/www.scientific.net/KEM.284-286.689 |
| Citation | C.C. Barrias et al., 2005, Key Engineering Materials, 284-286, 689 |
| Online since | April, 2005 |
| Authors | C.C. Barrias, C.C. Ribeiro, Daniel Rodrigues, M.C. Sá Miranda, Mario A. Barbosa |
| Keywords | Alginate, Calcium Titanium Phosphate, Cell Adhesion, Enzyme Release, Hydroxyapatite (HA), Microsphere |
| Abstract | In this study, the addition of calcium phosphate powders to an alginate matrix was evaluated as a strategy to modulate enzyme release-kinetics from alginate microspheres and, simultaneously, to improve cell adhesion to the polymer. Pre-adsorption of the enzyme to the ceramic powders resulted in a more adequate release pattern. The ratio of ceramic-to-polymer had a pronounced effect on osteoblast adhesion to microspheres. Cells were only able to spread on microspheres with the highest percentage of ceramic (0.4 w/w using a 1.5% w/v alginate solution). |
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