Paper Title:
Starch-Bioactive Glass Composite Microparticles: Bioactivity and Cellular Activity
  Abstract

In the present work we describe the synthesis of starch-based/BG 45S5 particles and their in vitro bioactivity behaviour by means of immersion in a simulated body fluid. The composite particles have shown to form a layer of Ca-P at their surface, whose nature was confirmed by chemical and morphological analysis. In order to evaluate the ability of these particles to be used as carriers for cell culture, undifferentiated rat cells were selected and parameters like cell adhesion, proliferation and expression of osteoblastic markers, were evaluated. The starch-based micro-particles have shown to support cellular activity, allowing cells to attach, proliferate and express specific markers while cultured in the particles surface. The final goal is to be able to use these particles as carriers for cells and simultaneously as in-situ forming constructs for tissue engineering and regenerative medicine applications.

  Info
Periodical
Key Engineering Materials (Volumes 284-286)
Main Theme
Edited by
Panjian Li, Kai Zhang and Clifford W. Colwell, Jr.
Pages
761-764
DOI
10.4028/www.scientific.net/KEM.284-286.761
Citation
G. A. Silva, O. P. Coutinho, R. L. Reis, "Starch-Bioactive Glass Composite Microparticles: Bioactivity and Cellular Activity", Key Engineering Materials, Vols. 284-286, pp. 761-764, 2005
Online since
April 2005
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: A.L. Oliveira, Isabel B. Leonor, P.B. Malafaya, C.M. Alves, H.S. Azevedo, Rui L. Reis
111
Authors: Di Zhang, Erik Vedel, Leena Hupa, Heimo O. Ylänen, Mikko Hupa
Abstract:In vitro behavior of 30 new glasses in the system Na2O-K2O-MgO-CaO-B2O3 -P2O5-SiO2 was investigated by immersing them into a simulated body...
481
Authors: Jie Weng, Bo Feng, Min Wang, Xing Dong Zhang
Abstract:The biomimetic approach of mineralization in vitro is adopted to investigate systematically the nucleation and growth of bone-like apatite...
277
Authors: Zhi Hua Zhou, Yong Yi Gao, Qing Feng Yi, Qing Quan Liu, Li Hua Liu
Abstract:The effect of poly(L-lactide-co-glycolide)/bioactive glass (PLGA/BG) on cell attachment, proliferation and differentiation of L929...
384
Authors: Sevil Yücel, Ismail Aydin, Didem Özçimen, Bilge Sema Tekerek, Özlem Yıldırım, Aycan Kabakcı
Abstract:Bone matrix consists of organic and inorganic components. Organic phase mainly contributes to flexibility of bone while inorganic phase being...
159