Paper Title:
Evaluation of a Chitosan Nano-Hybrid Material Containing Silanol Group and Calcium Salt as a Bioactive Bone Graft
  Abstract

A bioactive chitosan-siloxane nano-hybrid material was newly developed and evaluated for the potential application as a bone graft material. The chitosan which can be dissolved in organic solvent was synthesized by the reaction with phtalic anhydride (Ph-Chitosan) and it was then reacted with 3-isocyanatopropyl triethoxysilane (Si-Chitosan) in dimethylformamide. Following this, the Si-Chitosan was hydrolyzed and condensed to yield a hybrid sol-gel material (Si-O-Chitosan). The gelation was carried out for 1 week at ambient condition in a covered Teflon mold with a few pinholes and then dried under vacuum at room temperature for 48 h. The bioactivity of the chitosan nano-hybrid material was evaluated by examining the apatite forming ability in the simulated body fluid (SBF). The surface microstructure and functional groups of the specimen was analyzed by field emission scanning electron microscopy and Fourier transformed infrared spectroscopy, respectively. The crystal phases of the specimen before and after the bioactivity testing were analyzed by thin film X-ray diffractometry. Newly developed chitosan nano-hybrid material showed apatite-forming ability in the SBF within 1 week soaking and this ability was believed to come from the silanol group formed on the surface of Si-O-Chitosan and calcium salt which increased the ionic activity product of apatite in the SBF.

  Info
Periodical
Key Engineering Materials (Volumes 284-286)
Main Theme
Edited by
Panjian Li, Kai Zhang and Clifford W. Colwell, Jr.
Pages
765-768
DOI
10.4028/www.scientific.net/KEM.284-286.765
Citation
S. H. Rhee, Y. K. Lee, B. S. Lim, "Evaluation of a Chitosan Nano-Hybrid Material Containing Silanol Group and Calcium Salt as a Bioactive Bone Graft ", Key Engineering Materials, Vols. 284-286, pp. 765-768, 2005
Online since
April 2005
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Qi Feng Yu, Bang Cheng Yang, Yao Wu, Xing Dong Zhang
Abstract:In this study, alkali-heat treatment in NaOH solution and heat treatment, which could form amorphous sodium titanate on nanophase titania...
215
Authors: Isabel B. Leonor, Francisco Balas, Masakazu Kawashita, Rui L. Reis, Tadashi Kokubo, Takashi Nakamura
Abstract:Bioactive polymeric microspheres can be produced by pre-coating them with a calcium silicate solution and the subsequent soaking in a...
279
Authors: Kyu Hyeon Lee, Yong Keun Lee, Bum Soon Lim, Sung Baek Cho, Sang Hoon Rhee
Abstract:The poly(methyl methacrylate)/silica nano-composite made from trimethoxysilyl functionalized poly(methyl methacrylate) and dimethyl...
491