Paper Title:
Synthetic Biomimetic Nanostructured Hydroxyapatite
  Abstract

The incorporation of magnesium ions into the hydroxyapatite structure, which is of great interest for the developing of artificial bone, was performed starting from a wet chemical synthesis using magnesium chloride as Mg source. Different doping extents were attempted, four powders were produced and characterized in term of morphology, composition, solubility, thermal resistance,etc. in comparison with stoichiometric HA. In vitro tests with mesenchimal stem cells (MSCs) and human osteoblast like cells MG-63 cells were performed with the powder characterized with a biological-like doping of 5%Mg. The same powder was used, in form of granules, to carry out in vivo test by filling a defect in the femur on New Zealand White rabbits. All the tests showed better performance of the Mg doped apatite compared to stoichiometric HA, in agreement with the chemico-physical features of the material.

  Info
Periodical
Key Engineering Materials (Volumes 284-286)
Main Theme
Edited by
Panjian Li, Kai Zhang and Clifford W. Colwell, Jr.
Pages
949-952
DOI
10.4028/www.scientific.net/KEM.284-286.949
Citation
E. Landi, A. Tampieri, G. C. Celotti, M. Mattioli-Belmonte, G. Logroscino, "Synthetic Biomimetic Nanostructured Hydroxyapatite", Key Engineering Materials, Vols. 284-286, pp. 949-952, 2005
Online since
April 2005
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$32.00
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