Paper Title:
Construction of Biodegradable Multilayer Films via Layer-by-Layer Self-Assembly as Gene Delivery System
  Abstract

Films composed of alternating layers of protamine and DNA were constructed using the layer-by-layer method on quartz and subsequently studied the enzymic degradation in vitro. UV-visible spectrometry measurement indicated the uniform assembly of Protamine/DNA multilayer films. UV-visible spectrometry and fluorescence spectrometry results revealed that the Protamine/DNA multilayer films were in vitro enzymic biodegradable. The novel biodegradable multilayer of Protamine/DNA may have great potential for gene therapy applications in tissue engineering, medical implant etc.

  Info
Periodical
Key Engineering Materials (Volumes 288-289)
Edited by
Xingdong Zhang, Junzo Tanaka, Yaoting Yu and Yasuhiko Tabata
Pages
101-104
DOI
10.4028/www.scientific.net/KEM.288-289.101
Citation
K. F. Ren, J. Ji, J. C. Shen, "Construction of Biodegradable Multilayer Films via Layer-by-Layer Self-Assembly as Gene Delivery System", Key Engineering Materials, Vols. 288-289, pp. 101-104, 2005
Online since
June 2005
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Akira Sugawara, Kazuyoshi Uematsu, Kenji Toda, Mineo Sato
Abstract:Layered perovskite, K2NbO3F, includes rock-salt type KF blocks in a K2NiF4 type structure. After the KF blocks are dissolved selectively in...
99
Authors: Hui Jun Zhang, Jing Liang Cheng, Wen Zen, Guo Min Wang, Masaru Murao, Dian Zhong Wen, Akimitsu Hatta
Chapter 4: Ceramic
Abstract:It has been examined to disperse the Au nano-particles directly into liquid by replacing the solid substrate with low-vapor oil in a plasma...
999
Authors: Judita Puišo, Valentinas Baltrušaitis, Algirdas Lazauskas, Asta Guobienė, Igoris Prosyčevas, Pranas Narmontas
Abstract:Silver nanoparticles and polymethylmethacrylate (PMMA) nanocomposite was prepared in situ by photo-induced thermal reduction method....
80