Paper Title:
Tumor Targeting of Plasmid DNA by Dextran Conjugation Based on Metal Coordination
  Abstract

Tumor targeting of plasmid DNA was achieved through the conjugation of dextran derivative with chelate residue based on metal coordination. Spermine (Sm) was chemically introduced to the hydroxyl groups of dextran to obtain dextran-Sm derivative. A negative zeta potential of plasmid DNA became almost 0 mV by the Zn2+-coordinated conjugation with the dextran-Sm When the dextran-Sm-plasmid DNA conjugate with Zn2+ coordination was intravenously injected to mice subcutaneously bearing Meth-AR-1 fibrosarcoma, the dextran- Sm-plasmid DNA conjugate significantly enhanced the level of gene expression in the tumor, in contrast to free plasmid DNA..

  Info
Periodical
Key Engineering Materials (Volumes 288-289)
Edited by
Xingdong Zhang, Junzo Tanaka, Yaoting Yu and Yasuhiko Tabata
Pages
109-112
DOI
10.4028/www.scientific.net/KEM.288-289.109
Citation
H. Hosseinkhani, T. Aoyama, O. Ogawa, Y. Tabata, "Tumor Targeting of Plasmid DNA by Dextran Conjugation Based on Metal Coordination", Key Engineering Materials, Vols. 288-289, pp. 109-112, 2005
Online since
June 2005
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Price
$32.00
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