Paper Title:
An Implantable Immunosuppressive Cyclosporine Drug Delivery System
  Abstract

In the article a kind biodegradable drug carrier (glycolide-co-lactide-co-caprolactone) tricomponent copolymer (PGLC) was synthesized by ring opening copolymerization of glycolide (GA), lactide (LA) and ε-caprolactone (CL), and was used to manufacture an implantable drug preparation---Cyclosporine-PGLC drug delivery system (Cs-PGLC DDS).The Cs could slowly release from the Cs-PGLC DDS near linearly and last for a long time in vitro. A clinically significant Cs concentration in the cornea and anterior chamber could be achieved by implanting the Cs-PGLC DDS in anterior chamber. It was demonstrated that the Cs-PGLC DDS is a long-effective intraocular immunosuppressive agent for remaining corneal allograft clear and significantly prolong its survival time.

  Info
Periodical
Key Engineering Materials (Volumes 288-289)
Edited by
Xingdong Zhang, Junzo Tanaka, Yaoting Yu and Yasuhiko Tabata
Pages
125-128
DOI
10.4028/www.scientific.net/KEM.288-289.125
Citation
S. G. Wang, Q. Cai, J. Z. Bei, W. Y. Shi, L. X. Xie, "An Implantable Immunosuppressive Cyclosporine Drug Delivery System", Key Engineering Materials, Vols. 288-289, pp. 125-128, 2005
Online since
June 2005
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Price
$32.00
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