The regular spherical poly-D, L-lactic acid (PDLLA) nanoparticles containing DNR are produced using a double-emulsion solvent evaporation process. The products morphology is characterized by a laser light-scattering particle size analyzer and scanning electron microscopy. Results show a mean diameter in 546.9 nm with narrow size distribution and homogeneous particle production. The encapsulation efficiency is evaluated by UV spectra. The results indicate that drug contents and loading efficiency are 14.34% and 72.9% respectively, and the drug release profile shows a biphasic phenomenon.