Paper Title:
Spherical Porous Microparticle of Hydroxyapatite/Polysaccharides Nanocomposites
  Abstract

Nanocomposites of hydroxyapatite / chondroitin sulfate or hyaluronic acid were prepared by a wet method through a self-organization. In the nanocomposites, the c-axis of hydroxyapatite nanocrystals was oriented along the longitudinal axis of the aggregations. The spherical porous microparticles by using a spray drying method were developed with the size range of 1.0 to 20 µm, specific surface area of c.a. 100 m2g-1 and porosities of over 60vol%. No thermal decomposition of polysaccharides was occurred through the spray drying processes. It is note worth that the zeta-potential of the microparticles were gradually changed to be negative value of -35mV against the content of polysaccharides. The animal experiments implanted under the skin showed that the HAp/ChS had a good biocompatibility for 4 week implantations. The spherical microparticles will be applicable to create more complicated composites and drug carriers.

  Info
Periodical
Key Engineering Materials (Volumes 288-289)
Edited by
Xingdong Zhang, Junzo Tanaka, Yaoting Yu and Yasuhiko Tabata
Pages
159-162
DOI
10.4028/www.scientific.net/KEM.288-289.159
Citation
T. Ikoma, N. Azuma, S. Itoh, H. Omi, S. Nishikawa, S. Toh, M. Tanaka, "Spherical Porous Microparticle of Hydroxyapatite/Polysaccharides Nanocomposites", Key Engineering Materials, Vols. 288-289, pp. 159-162, 2005
Online since
June 2005
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Price
$32.00
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