Paper Title:
A Study on PELGE Nanoparticles as Controlled Drug Delivery Systems for Intravenous
  Abstract

The objective of this study was to evaluate the in vivo characteristics of poly (ethylene glycol)-poly (lacticacid-co-glycolicacid)-poly (ethylene- glycol) (PELGE) copolymers as drug carriers. In order to test this circulation time, mitoxantrone (DHAQ) was used as a model drug in this study. DHAQ nanoparticles (DHAQ-NP) were prepared, subsequently the DHAQ-NP were evaluated by measuring the drug concentration in plasma after intravenous administration via the tail vein of mice. The circulation time of the DHAQ-NP were tested. The results showed prolonged mitoxantrone (DHAQ) residence in systemic blood circulation.

  Info
Periodical
Key Engineering Materials (Volumes 288-289)
Edited by
Xingdong Zhang, Junzo Tanaka, Yaoting Yu and Yasuhiko Tabata
Pages
163-166
DOI
10.4028/www.scientific.net/KEM.288-289.163
Citation
Y. R. Duan, W.S. Liu, J. Liu, Z.R. Zhang, "A Study on PELGE Nanoparticles as Controlled Drug Delivery Systems for Intravenous", Key Engineering Materials, Vols. 288-289, pp. 163-166, 2005
Online since
June 2005
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Price
$32.00
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