Paper Title:
Fibrin-Reinforced Collagen Matrix Enhances Tissue Regeneration and Angiogenesis
  Abstract

The goal of this study was to investigate effects of fibrin reinforcement of collagen sponges on fibroblasts-mediated contraction and in vivo tissue regeneration, especially angiogenesis. Human dermal fibroblasts (HDFs)-populated collagen sponges reinforced with or without fibrin were cultivated via the free-floating method in vitro. They were then evaluated using xenogeneic implantation into nude mice. The HDFs-populated collagen sponges reinforced with fibrin exhibited significantly decreased HDFs-mediated contraction in vitro (p<0.05). Microvascular and cellular densities of the collagen sponges were significantly higher with fibrin than without (p<0.01). Cell ingrowths, neovascularization, and deposition of ECM matrix were more evenly distributed in the fibrin-reinforced collagen matrices. The results demonstrated that fibrin reinforcement of porous collagen sponges can reduce cell-mediated contraction in vitro while enhancing functional integration with surrounding tissue in vivo.

  Info
Periodical
Key Engineering Materials (Volumes 288-289)
Edited by
Xingdong Zhang, Junzo Tanaka, Yaoting Yu and Yasuhiko Tabata
Pages
257-260
DOI
10.4028/www.scientific.net/KEM.288-289.257
Citation
D. L. Seol, W. H. Jang, S. J. Lee, Y. I. Yang, "Fibrin-Reinforced Collagen Matrix Enhances Tissue Regeneration and Angiogenesis", Key Engineering Materials, Vols. 288-289, pp. 257-260, 2005
Online since
June 2005
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Price
$32.00
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