Paper Title:
The Study of Collagen-HA Composite with Incorporated BMP as Bone Tissue Engineering Scaffold
  Abstract

Collagen-HA scaffolds were prepared by a phase-separation technique, cross-linked by formaldehyde or carbodiimide(EDC)/N-hydroxysuccinimide(NHS), which is also used to covalently attach chondroitin sulfate(CS) to the scaffold. BMP was incorporated into the scaffold by adsorption. The scaffolds were characterized by SEM and ESCA. Rat mesenchymal stem cell(MSCs) was seeded into the scaffold and cultured to form a cell/scaffold construct. The ectopic osteoinduction of the scaffolds were evaluated in vivo. The results show that the scaffolds are porous with three-dimensionality, have good cell compatibility and osteoinduction. Attachment of CS can improve the adhesion and differentiation of cells.

  Info
Periodical
Key Engineering Materials (Volumes 288-289)
Edited by
Xingdong Zhang, Junzo Tanaka, Yaoting Yu and Yasuhiko Tabata
Pages
261-264
DOI
10.4028/www.scientific.net/KEM.288-289.261
Citation
L.R. Liu, L.H. Zhang, F.J. Wang, Q.Q. Zhang, "The Study of Collagen-HA Composite with Incorporated BMP as Bone Tissue Engineering Scaffold", Key Engineering Materials, Vols. 288-289, pp. 261-264, 2005
Online since
June 2005
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Price
$32.00
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