Paper Title:
PEG-Containing Polymeric Films and Gels as Postoperative Tissue Adhesion Barriers
  Abstract

This study was designed to evaluate the effect of polyethylene glycol (PEG) and nonsteroidal anti-inflammatory drug (ibuprofen) on the prevention of postoperative tissue adhesion. For this, we synthesized poly(L-lactic acid)-PEG diblock copolymers and used them to prepare ibuprofen-loaded films as tissue adhesion barrier films. We also prepared lower critical solution temperature (LCST)-controllable Pluronic F127/F68 mixtures including mildly crosslinked alginate and ibuprofen as tissue adhesion barrier gels. The prepared films and gels with/without ibuprofen were evaluated by the observations of peritoneal tissue adhesion via animal study using a rat model.

  Info
Periodical
Key Engineering Materials (Volumes 288-289)
Edited by
Xingdong Zhang, Junzo Tanaka, Yaoting Yu and Yasuhiko Tabata
Pages
373-376
DOI
10.4028/www.scientific.net/KEM.288-289.373
Citation
A.K. Go, J.K. Kim, S. H. Oh, S. H. Yuk, J. H. Lee, "PEG-Containing Polymeric Films and Gels as Postoperative Tissue Adhesion Barriers", Key Engineering Materials, Vols. 288-289, pp. 373-376, 2005
Online since
June 2005
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Price
$32.00
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