Paper Title:
In Vitro Degradation of Medical Polyacrylamide Hydrogel I.Oxidation
  Abstract

Polyacrylamide (PAM) was usually atoxic, stable. Its hydrogel (PAMG) has been used in plastic and aesthetic surgery more than 10 years in P.R.China, Ukraine and Russia. But there were some complications with PAMG injected in patients. Considering the complicacy in vivo, it was necessary to study the PAMG’s stability. In this paper, H2O2 was added in PAMG in vitro and acrylamide (AM) content after oxidating was determined using HPLC method. Detection limit for AM can be achieved in the parts-per-billion rang. The AM content in supernatant at 0.5, 1,2 and 3 hr after oxidating of PAMG was 1.27e-8g/ml, 1.35e-8g/ml, 1.03e-7g/ml and 2.74e-7g/ml, respectively. The AM content in supernatant of PAMG was 7.70e-9g/ml. These results indicated that PAMG can be degraded to AM by hydroxyl radical. Under the same condition, the AM content was stable. So, AM can exist for a while when it was produce by degrading of PAMG. That can increase the toxicity of PAMG.

  Info
Periodical
Key Engineering Materials (Volumes 288-289)
Edited by
Xingdong Zhang, Junzo Tanaka, Yaoting Yu and Yasuhiko Tabata
Pages
397-400
DOI
10.4028/www.scientific.net/KEM.288-289.397
Citation
Z. Y. Wan, T. F. Xi, P. Zhao, C. X. Fan, Y. Sun, Z.G. Feng, "In Vitro Degradation of Medical Polyacrylamide Hydrogel I.Oxidation", Key Engineering Materials, Vols. 288-289, pp. 397-400, 2005
Online since
June 2005
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