Paper Title:
Biomimetic Mineralization and Bioactivity of Phosphorylated Chitosan
  Abstract

Phosphorylated chitosans were synthesized as templates to manipulate hydroxyapatite (HA) crystal nucleation, growth and microstructure. Two kinds of insoluble phosphorylated chitosan were soaked in saturated Ca(OH)2 solution for 4 d and in 1.5× SBF (simulated body fluid) solutions for 14 d at 37 °C for biomimetic mineralization. A lower [P]-content of phosphorylated chitosan promoted greater mineralization than higher [P]-content. Phosphorylated chitosan inhibited osteoblast proliferation and differentiation in vitro, while calcium phosphate phosphorylated chitosan composites did not.

  Info
Periodical
Key Engineering Materials (Volumes 288-289)
Edited by
Xingdong Zhang, Junzo Tanaka, Yaoting Yu and Yasuhiko Tabata
Pages
429-432
DOI
10.4028/www.scientific.net/KEM.288-289.429
Citation
Z. Q. Chen, Q. L. Li, Q. Zen, G. Li, H. B. Jiang, L. Liu, B. W. Darvell, "Biomimetic Mineralization and Bioactivity of Phosphorylated Chitosan ", Key Engineering Materials, Vols. 288-289, pp. 429-432, 2005
Online since
June 2005
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Price
$32.00
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