Paper Title:
Application of Microbial Polyesters-Polyhydroxyalkanoates as Tissue Engineering Materials
  Abstract

Poly(hydroxybutyrate-co-hydroxyhexanoate) (PHBHHx) has improved mechanical properties over the existing PHA and our results have shown that PHBHHx has better biocompatibility over polyhydroxybutyrate (PHB) and polylactic acid (PLA). Surface treatment with lipases dramatically changed the material surface properties and increased the biocompatibility of the PHBHHx. PHBHHx and its PHB blends had been used to make three dimensional structures and it has been found that cartilage, osteoblast, and fibroblasts all showed strong growth on the PHBHHx scaffolds. The growth was much better compared with PLA. The molecular studies also showed that mRNA encoding cartilages were strongly expressed when cartilage cells were grown on the PHBHHx. As PHBHHx has strong mechanical properties, easily processible and biodegradable, this material can be used to develop a new class of tissue engineering materials.

  Info
Periodical
Key Engineering Materials (Volumes 288-289)
Edited by
Xingdong Zhang, Junzo Tanaka, Yaoting Yu and Yasuhiko Tabata
Pages
437-440
DOI
10.4028/www.scientific.net/KEM.288-289.437
Citation
G. Q. Chen, Q. Wu, Y. W. Wang, Z. Zheng, "Application of Microbial Polyesters-Polyhydroxyalkanoates as Tissue Engineering Materials", Key Engineering Materials, Vols. 288-289, pp. 437-440, 2005
Online since
June 2005
Export
Price
$32.00
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