Chitosan Derivatives as Gene Carriers |
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| Journal | Key Engineering Materials (Volumes 288 - 289) |
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| Volume | Advanced Biomaterials VI |
| Edited by | Xingdong Zhang, Junzo Tanaka, Yaoting Yu and Yasuhiko Tabata |
| Pages | 97-100 |
| DOI | 10.4028/www.scientific.net/KEM.288-289.97 |
| Citation | Tae Hee Kim et al., 2005, Key Engineering Materials, 288-289, 97 |
| Online since | June, 2005 |
| Authors | Tae Hee Kim, In Kyu Park, Su Il Kim, Hwan Jeong Jeong, Hee Seung Bom, Chong Su Cho |
| Keywords | Chemical Modification, Chitosan (CS), Gene Carrier, Transfection Efficiency |
| Abstract | Chitosan has been considered to be a good candidate for gene delivery system, since it is already known as a biocompatible, biodegradable, and low toxic material with high cationic potential. However, low specificity and low transfection efficiency of chitosan need to be overcome prior to clinical trial. In this review paper, chemical modification of chitosan for enhancement of cell specificity and transfection efficiency was explained. Also, chemical modification of chitosan for the stability of chitosan/DNA complexes was reviewed. |
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