Plastic profiles produced by extrusion die are cooled down and calibrated by calibrators, so it is an important basis to solve design problems of calibrators that how to obtain the transient temperature field of cooling process of hot plastic profiles. Based on the analysis of heat transfer ways during the cooling process, computation model, initial and boundary conditions are studied deeply, and then ANSYS is applied to simulate the cooling process of plastic profiles. Lastly, the transient temperature field of the cooling process is gain. Results of the numerical simulation show that the temperature drops of functional blocks, main-walls and inner-ribs are reduced in order of priority. Based on the results, the cooling water channels can be adjusted in order to improve the distributing uniformity of temperature field. All this is effective to the calibrators’ design.