Vanadium alloys in the composition range around V-4Cr-4Ti have been proposed as candidate materials for fusion reactor applications and structures. These applications will require detailed characterization of constitutive and fracture properties. This study is aimed at understanding the basic constitutive and fracture mechanisms in vanadium alloys. Understanding of the basic constitutive and fracture mechanisms is achieved through a series of mechanical tests. These test results are combined with quantitative models of the underlying macro- and micromechanics. In addition to these experimental studies, finite element analysis (FEA) techniques are used to determine stress and strain fields to verify the constitutive law used in the fracture specimens.