The current paper investigated the phenomena of room temperature creep at the crack tip and its influence on fatigue crack growth behavior of a 304 stainless steel. From the experiments, a time-dependent deformation is obviously observed under various stress intensity factors. The deformation depends on stress intensity factor as well as load history. Both acceleration and retardation of fatigue crack growth are found after room temperature creep, which rest on load patterns. A distinct marking line was seen on the fracture surface following the holding period. It is proposed that the crack propagation mode changed after the hold time.