A thermomechanical fatigue (TMF) life prediction model for ferritic stainless steel, used in exhaust manifold of automobile, was developed based on Tomkins’ two-dimensional crack propagation model. Low-cycle fatigue (LCF) and TMF tests were carried out in a wide temperature range from 200 to 650°C. New concept of plastic strain range on TMF was proposed. Effective stress concept was introduced to get a reasonable stress range in TMF hysteresis loop. The proposed model predicted TMF life within 2X scatter band. The experimental results reveal that TMF life is about 10% of isothermal fatigue life.