Paper Title:
High Cellular Biocompatibility of Calcium Carbonate / Poly (Lactic Acid) Composites Doped with Silicon
  Abstract

Silicon-doped calcium carbonate / poly (lactic acid) composites (Si-CCPC) were estimated in cellular biocompatibility with culture tests using osteoblast-like cells (MC3T3-E1) and mesenchymal stem cells (MSC). The cellular biocompatibility of Si-CCPC was enhanced by coating with bone-like hydroxycarbonate apatite (b-HA) formed by simulated body fluid immersion. The b-HA was formed on Si-CCPC after 3-days of immersion and closely bonded with Si-CCPC. Numerous MC3T3-E1 and MSC showed good adhesion on the b-HA with extending their lamellipodia. The number of adhering MC3T3-E1 on Si-CCPC coated with the b-HA was higher than that on Si-CCPC. The b-HA has excellent biocompatibility and silicon is regarded to stimulate osteoblast and bone formation in vivo and vitro. The b-HA containing silicon on Si-CCPCis expected to enhance the cellular adheresion, proliferation and differentiation.

  Info
Periodical
Key Engineering Materials (Volumes 309-311)
Main Theme
Edited by
Takashi Nakamura, Kimihiro Yamashita and Masashi Neo
Pages
1113-1116
DOI
10.4028/www.scientific.net/KEM.309-311.1113
Citation
A. Obata, H. Maeda, T. Kasuga, "High Cellular Biocompatibility of Calcium Carbonate / Poly (Lactic Acid) Composites Doped with Silicon", Key Engineering Materials, Vols. 309-311, pp. 1113-1116, 2006
Online since
May 2006
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$32.00
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