Paper Title:
Collagen-Calcium Phosphate Hybrids for Bone Grafts: A Novel Route Leading to High Initial Strengths
  Abstract

An organic/inorganic composite hydrogel route was used to prepare collagen-calcium phosphate hybrids with high mechanical strengths, via in-situ mineral synthesis during collagen fibrillogenesis followed by dehydration. An array of characterization techniques including X-ray diffraction and Fourier transform infrared spectroscopy analyses confirmed that the final products are analogous to natural bone. A three-point bending strength of 70 MPa, much higher than the values reported in the literature, was recorded in the present case, due to the three dimensional network structure achieved between inorganic and organic phases. This innovative method provides an efficient route to produce bone grafts with the desirable mechanical properties which are dependent upon the actual inorganic/organic ratio and water content.

  Info
Periodical
Key Engineering Materials (Volumes 309-311)
Main Theme
Edited by
Takashi Nakamura, Kimihiro Yamashita and Masashi Neo
Pages
1185-1190
DOI
10.4028/www.scientific.net/KEM.309-311.1185
Citation
X. D. Li, X. M. Wang, X. Y. Lin, J. M. Jiang, X. D. Zhang, "Collagen-Calcium Phosphate Hybrids for Bone Grafts: A Novel Route Leading to High Initial Strengths ", Key Engineering Materials, Vols. 309-311, pp. 1185-1190, 2006
Online since
May 2006
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Ana Cristina P. Machado, Marize Varella de Oliveira, Robson Pacheco Pereira, Yasmin R. Carvalho, Carlos Alberto Alves Cairo
Abstract:The osseointegration of porous titanium implants was evaluated in the present work. Implants were fabricated from ASTM grade 2 titanium by a...
179
Authors: Cornelia Ganz, W. Xu, G. Holzhüter, W. Götz, B. Vollmar, Th. Gerber
Abstract:Various bone graft substitutes were used in clinical practise in the treatment of bone defects after trauma or osteoporosis. Many synthetic...
732
Authors: Jayachandran Venkatesan, Se Kwon Kim
Chapter 4: Ceramic Materials / Superconducting Materials
Abstract:In the recent years, significant developments have been achieved with chitosan and hydroxyapatite (HAp) scaffolds for bone tissue...
212
Authors: Vincent Irawan, Tomomei Sugiyama, Toshiyuki Ikoma
Chapter 3: Bioceramics in Practice of Scaffolds, Tissue Engineering and Implantation
Abstract:Pore alignment is a vital step to obtain bone-mimicking microstructure in collagen-based scaffold. The porous structure can be controlled by...
121