Paper Title:
Performance of Osteoinductive Biphasic Calcium-Phosphate Ceramic in a Critical-sized Defect in Goats
  Abstract

Osteoinductive biomaterials are able of inducing bone formation at ectopic, i.e. extraskeletal implantation sites. It is, however, important to investigate whether osteoinductive biomaterials perform better when implanted orthotopically as well, in particular in clinically relevant criticalsized defects. In this study, an osteoinductive and a non-osteoinductive biphasic calcium-phosphate (BCP) ceramic were compared in a critical-sized iliac wing defect that allows for paired comparison. After 12 weeks of implantation in the critical-sized defect, the osteoinductive BCP1150 ceramic showed significantly more bone than the non-osteoinductive BCP1300 ceramic. In addition, the analysis of fluorochrome markers, which were administered to the animals 4, 6 and 8 weeks after implantation in order to visualize the bone growth dynamics, showed an earlier start of bone formation in BCP1150 as compared to BCP1300. Significantly better performance of osteoinductive ceramic in a critical-sized orthotopic defect in a large animal model in comparison to the non-osteoinductive ceramic suggests osteoinduction to be clinically relevant.

  Info
Periodical
Key Engineering Materials (Volumes 309-311)
Main Theme
Edited by
Takashi Nakamura, Kimihiro Yamashita and Masashi Neo
Pages
1303-1306
DOI
10.4028/www.scientific.net/KEM.309-311.1303
Citation
P. Habibovic, M. van den Doel, C. A. van Blitterswijk, K. de Groot, "Performance of Osteoinductive Biphasic Calcium-Phosphate Ceramic in a Critical-sized Defect in Goats ", Key Engineering Materials, Vols. 309-311, pp. 1303-1306, 2006
Online since
May 2006
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Anke Bernstein, Renate Gildenhaar, Doreen Nöbel, Georg Berger
623
Authors: Christophe Drouet, Ronan Barré, Gérard Brunel, Gérard Dechambre, Edmond Benqué, Christèle Combes, Christian Rey
Abstract:Apatite/β−TCP particles exhibiting non-conventional urchin-like morphology were prepared by hydrothermal synthesis. Their implantation in...
1237
Authors: Jick Soo Jhun, Hui Suk Yun, Eui Kyun Park, Hong In Shin
Abstract:To improve the efficiency of osteogenic repair, we compared 3 types of round granular bone substitutes composed of hydroxyapatite (HA) in a...
143
Authors: H. Valiense, G.V.O. Fernandes, B. Moura, J. Calasans-Maia, A. Alves, Antonella M. Rossi, J.M. Granjeiro, M. Calasans-Maia
Abstract:The objective of this study was to investigate the bone repair of carbonate apatite (cHA) in comparison to hydroxyapatite (HA, control...
258
Authors: Lan Lei Wang, Ji Hua Li, Yong Tao Xie, Pi Shan Yang, Yun Mao Liao, Gong Ling Guo
Chapter 2: Materials Science and Engineering
Abstract:The aim of the present study is to investigate the efficacy of nanobiphasic calcium phosphate (nanoBCP) bioceramic in the treatment of...
422