Paper Title:
Influence of Physico-Chemical Properties, Macro- and Microstructure on Osteoinductive Potential of Calcium-Phosphate Ceramics
  Abstract

Osteoinduction by biomaterials that initially do not contain bone morphogenetic proteins and other growth factors has been shown to be a real phenomenon by many investigators in the past two decades. Although it is well-known that a material needs to meet very specific requirements in terms of physico-chemical and structural properties in order to be osteoinductive, the underlying mechanism of osteoinduction is not fully unraveled yet. In the present study we investigated parameters which are of importance for the osteoinductive potential of biomaterials by comparing four biphasic calcium-phosphate and a carbonated apatite ceramic. The results showed that the presence of micropores, by which the specific surface area of a material is increased, is essential for the material’s osteoinductivity. However, if the surface area is too high, or material is too resorbable because of its chemical composition, the implant might degrade and lose its shape. In that case, ectopic bone formation does not occur, as a relatively stable surface is needed to facilitate new bone growth.

  Info
Periodical
Key Engineering Materials (Volumes 309-311)
Main Theme
Edited by
Takashi Nakamura, Kimihiro Yamashita and Masashi Neo
Pages
1307-1310
DOI
10.4028/www.scientific.net/KEM.309-311.1307
Citation
P. Habibovic, T.M. Sees, C. A. van Blitterswijk, K. de Groot, "Influence of Physico-Chemical Properties, Macro- and Microstructure on Osteoinductive Potential of Calcium-Phosphate Ceramics ", Key Engineering Materials, Vols. 309-311, pp. 1307-1310, 2006
Online since
May 2006
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: You Rong Duan, Cheng Yong Wang, Ji Yong Chen, Xing Dong Zhang
351
Authors: Suk Young Kim, Chang Kuk You, Jae Ho Jeong, Eui Kyun Park, Shin Yoon Kim, Hong In Shin
Abstract:As a part of the efforts to develop a suitable scaffold optimizing bone regeneration that has similar physical properties to bone, we...
631
Authors: Anke Bernstein, Renate Gildenhaar, Doreen Nöbel, Georg Berger
623
Authors: G. Daculsi, I. Khairoun, Racquel Z. LeGeros, Françoise Moreau, Paul Pilet, Xavier Bourges, Pierre Weiss, Olivier Gauthier
811
Authors: Christophe Drouet, Ronan Barré, Gérard Brunel, Gérard Dechambre, Edmond Benqué, Christèle Combes, Christian Rey
Abstract:Apatite/β−TCP particles exhibiting non-conventional urchin-like morphology were prepared by hydrothermal synthesis. Their implantation in...
1237