Paper Title:
F-Substituted Carbonate Apatite for Promoting Bone Formation
  Abstract

Abstract. Fluoride (F-)-substituted type-B carbonate-containing hydroxyapatites (CHAPs) were prepared as bone substitutes with a F-releasing ability. The F- contents in the F-substituted CHAPs were 16-22 times larger than that in normal adult human bones. The carbonate contents in the F-substituted CHAPs corresponded to that in human bones. The F-substituted CHAPs released F- in an acetic acid – sodium acetate buffer at pH 4.9; within only 3 h, the F- concentration in the buffer increased to more than 63.9 µg L-1, which was 1.5~8.9 times higher than that in a body fluid of normal adult humans. Although the F- concentration rapidly decreased probably due to the precipitation of a certain phase containing F-, the F-substituted CHAPs exhibited the ability to increase the F- concentration in a body fluid by bone resorption. Therefore, it is expected that the F-substituted CHAPs will be feasible as a F-releasing material for promoting bone formation.

  Info
Periodical
Key Engineering Materials (Volumes 309-311)
Main Theme
Edited by
Takashi Nakamura, Kimihiro Yamashita and Masashi Neo
Pages
141-144
DOI
10.4028/www.scientific.net/KEM.309-311.141
Citation
Y. Sogo, D. Yokoyama, A. Ito, A. Yamazaki, R. Z. LeGeros, "F-Substituted Carbonate Apatite for Promoting Bone Formation", Key Engineering Materials, Vols. 309-311, pp. 141-144, 2006
Online since
May 2006
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$32.00
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