Paper Title:
Cytotoxicity of Various Calcium Phosphate Ceramics
  Abstract

The cytotoxicity of five calcium phosphate ceramics, hydroxyapatite (HAp), flouroapatite (FAp), α-tricalcium phosphate (α-TCP), β-tricalcium phosphate (β-TCP) and tetracalcium phosphate (TTCP), was investigated. Based on the guidelines of biological test for medical devices in Japan, a cytotoxicity test of these calcium phosphates was carried out using Chinese hamster V79 lung fibroblasts. The cytotoxic study revealed that FAp and α-TCP showed high cytotoxicities. From various analyses, it was considered that the cytotoxicity of the FAp was due to fluorine ions extracted in a culture medium and the cytotoxicity of α-TCP resulted from a decrease in pH of the medium by the phosphoric acid, which produced by hydrolysis of( the α-TCP.

  Info
Periodical
Key Engineering Materials (Volumes 309-311)
Main Theme
Edited by
Takashi Nakamura, Kimihiro Yamashita and Masashi Neo
Pages
263-266
DOI
10.4028/www.scientific.net/KEM.309-311.263
Citation
M. Tamai, R. Nakaoka, T. Tsuchiya, "Cytotoxicity of Various Calcium Phosphate Ceramics", Key Engineering Materials, Vols. 309-311, pp. 263-266, 2006
Online since
May 2006
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Price
$32.00
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