Paper Title:
Preparation of Hollow Y2O3 Microspheres for In Situ Radiotherapy of Cancer by Enzymatic Reaction
  Abstract

Chemically durable microspheres 20−30 µm in diameter containing a large amount of yttrium are useful for in situ radiotherapy of cancer as they can be activated by neutron bombardment to become β-emitters and can be injected in the vicinity of the cancer to provide a large localized dose of β-radiation. In this study, preparation of hollow Y2O3 microspheres using an enzymatic reaction was attempted, and the structure and chemical durability of the resulting microspheres were investigated. Hollow Y2O3 microspheres 20–30 &m in diameter were successfully prepared by this enzymatic method. The outer surface of the microspheres was smooth and dense, whereas the inner parts had a honeycombed structure. In simulated body fluids at pH 6 and 7, the hollow Y2O3 microspheres showed high chemical durability.

  Info
Periodical
Key Engineering Materials (Volumes 309-311)
Main Theme
Edited by
Takashi Nakamura, Kimihiro Yamashita and Masashi Neo
Pages
461-464
DOI
10.4028/www.scientific.net/KEM.309-311.461
Citation
M. Kawashita, Y. Takayama, T. Kokubo, G. H. Takaoka, N. Araki, M. Hiraoka, "Preparation of Hollow Y2O3 Microspheres for In Situ Radiotherapy of Cancer by Enzymatic Reaction", Key Engineering Materials, Vols. 309-311, pp. 461-464, 2006
Online since
May 2006
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Price
$32.00
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