Thin Sol-Gel Films on Fracture Fixation Material for the Controlled Release of Antibiotics

Previously, the properties of room temperature processed silica sol gel (also called xerogels) as resorbable and biocompatible controlled release systems were described. It was demonstrated that drugs and macromolecules with a variety of properties and characteristics could be released in a controlled manner. In this study, we focus on the synthesis of antibacterial thin solgel films on intramedullary nails and fracture fixation materials. We determine the effect of processing parameters on the in vitro properties and demonstrated a time- and load- dependent release of vancomycin from the film. This study suggests that thin sol-gel films hold great promise for the prevention and treatment of bone infections.