Innovative Technique for the Preparation of Porous Bilayer Hydroxyapatite/Chitosan Scaffolds for Osteochondral Applications |
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| Journal | Key Engineering Materials (Volumes 309 - 311) |
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| Volume | Bioceramics 18 |
| Edited by | Takashi Nakamura, Kimihiro Yamashita and Masashi Neo |
| Pages | 927-930 |
| DOI | 10.4028/www.scientific.net/KEM.309-311.927 |
| Citation | J. Miguel Oliveira et al., 2006, Key Engineering Materials, 309-311, 927 |
| Online since | May, 2006 |
| Authors | J. Miguel Oliveira, S.S. Silva, João F. Mano, Rui L. Reis |
| Keywords | Bilayer Scaffolds, Chitosan (CS), Hydroxyapatite (HA), Osteochondral Applications |
| Abstract | In this study, it is shown that it is possible to develop 3D-porous bilayer hydroxyapatite/chitosan scaffolds by means of combining a sintering and a freeze-drying technique. Scanning electron microscopy (SEM/EDS) studies revealed that the scaffolds possess a well-defined orientation and anisotropic porosity, with pore size ranging between 50-350 µm. Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) patterns evidenced the formation of crystalline hydroxyapatite. Moreover, the compression tests revealed that these scaffolds have adequate mechanical properties for being used in tissue engineering of osteochondral defects. |
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