High-speed machining (HSM) has received great interest because it leads to an increase of productivity and a better workpiece surface quality. However, tool wear increases dramatically due to the high temperature at the tool/workpiece interface. Proper selection of cutting tool and cutting parameters is the key process in high-speed machining. In this paper, experiments have been conducted to high speed milling pearlitic cast iron with different tool materials, including polycrystalline cubic boron nitrogen, ceramics and coated cemented carbides. Wear curves and tool life curves have been achieved at various cutting speeds with different cutting tools. If efficiency is considered, Polycrystalline Cubic Boron Nitrogen cutting tool materials are preferred in finish and semi-finish machining. According to the different hardness of cast iron, the appropriate range of cutting speed is from 850 m/min to 1200m/min.