A new type of ultrasonic spray nozzle was fabricated employing PZT and Pb-free piezoelectric device. The spray nozzle was designed to disperse chemicals in a water treatment mixing tank. The piezoelectrics were packaged in an aluminum case with silicone resin for the aqueous solution proof packaging. Chemicals were dispersed with high efficiency, and the ultrasonic fine particle spraying was able to reduce the chemicals consumption. The removal efficiencies of heterotrophic bacteria and Escherichia coli by chemicals injected using designed ultrasonic spray nozzle were higher than the conventional methods.