Paper Title:
Label-Free DNA Detection Using a Near-Field Microwave
  Abstract

A near-field scanning microwave microscope (NSMM) is used to study the physical properties of DNA strands with a specific sequence and image lamda-DNA bundles. After the hybridization process between target and capture sequences, specific DNA binding events leads to microwave reflection coefficient (S11) changes of the NSMM. These changes are caused by a modification of the physical dielectric constant due to sequence specific DNA binding. This study demonstrates significant potential of the NSMM as a nondestructive and noncontact tool to detect DNA strands without a target-probe amplification process and as a valuable technique to understand the physical property of DNA.

  Info
Periodical
Key Engineering Materials (Volumes 321-323)
Edited by
Seung-Seok Lee, Joon Hyun Lee, Ik Keun Park, Sung-Jin Song, Man Yong Choi
Pages
1040-1043
DOI
10.4028/www.scientific.net/KEM.321-323.1040
Citation
K. J. Lee, A. Babajayan, S. H. Kim, "Label-Free DNA Detection Using a Near-Field Microwave", Key Engineering Materials, Vols. 321-323, pp. 1040-1043, 2006
Online since
October 2006
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Price
$32.00
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