This study aimed to investigate the hypothesis that administration of the air with 30% oxygen compared with normal air (21% oxygen) enhances verbal cognitive functioning through increased activation in the brain. Nine male college students participated in the study. The experiment consisted of two runs, one for verbal cognition task with normal air (21% oxygen) and the other for verbal cognition task with hyperoxic air (30% oxygen). Functional brain images were taken with a 3T MRI using the single-shot EPI method. From the results of the verbal behavioral analysis, the accuracy rate was enhanced with 30% oxygen administration when compared to 21% oxygen. The activities were observed at the occipital, parietal, temporal and frontal lobes during both 21% and 30% oxygen administration. There were more activations observed at the right middle frontal gyrus, right inferior frontal gyrus, right superior frontal gyrus, cingulate gyrus, left middle temporal gyrus, and left fusiform gyrus with 30% oxygen administration. These results suggest that a higher concentration of breathed oxygen increases saturation of blood oxygen in the brain, and facilitates verbal performance.