Paper Title:
Three-Dimensional Microfabrication System for Scaffolds in Tissue Engineering
  Abstract

Understanding chondrocyte behavior inside complex, three-dimensional environments with controlled patterning of geometrical factors would provide significant insights into the basic biology of tissue regenerations. One of the fundamental limitations in studying such behavior has been the inability to fabricate controlled 3D structures. To overcome this problem, we have developed a three-dimensional microfabrication system. This system allows fabrication of predesigned internal architectures and pore size by stacking up the photopolymerized materials. Photopolymer SL5180 was used as the 3D microfabricated scaffolds. The results demonstrate that controllable and reproducible inner-architecture can be fabricated. Chondrocytes from human nasal septum were cultured in 3D scaffolds for cell adhesion behavior. Such 3D scaffolds might provide effective key factors to study cell behavior in complex environments and could eventually lead to optimum design of scaffolds in various tissue regenerations such as cartilage, bone, etc. in a near future.

  Info
Periodical
Key Engineering Materials (Volumes 326-328)
Edited by
Soon-Bok Lee and Yun-Jae Kim
Pages
723-726
DOI
10.4028/www.scientific.net/KEM.326-328.723
Citation
S. J. Lee, B. Kim, J. S. Lee, S. W. Kim, M. S. Kim, J. S. Kim, G. B. Lim, D. W. Cho, "Three-Dimensional Microfabrication System for Scaffolds in Tissue Engineering", Key Engineering Materials, Vols. 326-328, pp. 723-726, 2006
Online since
December 2006
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Price
$32.00
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