Calcium sulphate hemihydrate/α-tricalcium phosphate (CSH-TCP) cement are promising bone replacement materials with controllable-degradation rate and setting time and excellent delivery matrix for sustained release. In the present study, setting behaviors of binary bone cement composed of α-TCP and CSH and release of ciprofloxacin from this cement were investigated in vitro. XRD and SEM results demonstrated that the setting products of CSH-TCP cement were calcium sulphate dihydrate with pillar morphology and hydroxyapatite with needle morphology. Only 20% ciprofloxacin was released from CSH-TCP cement in 7 days in vitro. Fibers of hydroxyapatite enhanced strength of binary cement through fiber-reinforce mechanism. At initial stage (less than 100 hours), the release of ciprofloxacin from CSH-TCP cement was diffusion control, and at subsequent stage the release was matrix dissolution & diffusion control.