Paper Title:
Setting Behaviors and Ciprofloxacin Hydrochloride Sustained Release of CSH-TCP Binary Cement
  Abstract

Calcium sulphate hemihydrate/α-tricalcium phosphate (CSH-TCP) cement are promising bone replacement materials with controllable-degradation rate and setting time and excellent delivery matrix for sustained release. In the present study, setting behaviors of binary bone cement composed of α-TCP and CSH and release of ciprofloxacin from this cement were investigated in vitro. XRD and SEM results demonstrated that the setting products of CSH-TCP cement were calcium sulphate dihydrate with pillar morphology and hydroxyapatite with needle morphology. Only 20% ciprofloxacin was released from CSH-TCP cement in 7 days in vitro. Fibers of hydroxyapatite enhanced strength of binary cement through fiber-reinforce mechanism. At initial stage (less than 100 hours), the release of ciprofloxacin from CSH-TCP cement was diffusion control, and at subsequent stage the release was matrix dissolution & diffusion control.

  Info
Periodical
Key Engineering Materials (Volumes 330-332)
Main Theme
Edited by
Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu
Pages
1017-1020
DOI
10.4028/www.scientific.net/KEM.330-332.1017
Citation
D. Zhang, Q. Cheng, H. Li, "Setting Behaviors and Ciprofloxacin Hydrochloride Sustained Release of CSH-TCP Binary Cement", Key Engineering Materials, Vols. 330-332, pp. 1017-1020, 2007
Online since
February 2007
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$32.00
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