Paper Title:
Attenuation of Osteoclastic Activity Induced by Zinc-Containing Tricalcium Phosphate
  Abstract

Osteoclasts isolated from rabbits were cultured on zinc-containing tricalcium phosphate (ZnTCP) disks with zinc contents of 0.316 and 0.633 wt%, and on β-tricalcium phosphate (TCP) disks with nearly identical porosities, grain sizes and surface roughnesses. ZnTCPs directly suppressed the resorption activity of mature osteoclasts by enhancing apoptosis. We hypothesized that resorbing osteoclasts attached to ZnTCP locally accumulate zinc ions within the space defined by the clear zone during resorption, which in turn leads to apoptosis induction, even though the change in chemical composition of the culture medium is very small.

  Info
Periodical
Key Engineering Materials (Volumes 330-332)
Main Theme
Edited by
Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu
Pages
1071-1074
DOI
10.4028/www.scientific.net/KEM.330-332.1071
Citation
Y. Yamada, A. Ito, H. Kojima, M. Sakane, S. Miyakawa, T. Uemura, R. Z. LeGeros, "Attenuation of Osteoclastic Activity Induced by Zinc-Containing Tricalcium Phosphate", Key Engineering Materials, Vols. 330-332, pp. 1071-1074, 2007
Online since
February 2007
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