Paper Title:
Mechanical Properties of Living Adherent Cells: Interaction of Cell and Shear Flow
  Abstract

To investigate the interaction of the adherent cell and shear flow, a compound drop model was developed to simulate a living adherent cell adhered to a smooth substrate, and a two dimensional computational fluid dynamics (CFD) was conducted to solve the model equations. The results showed that the deformability of the cell increases with Reynolds number and initial contact angle. The nucleus deforms with the cell, and the deformation index of the cell is greater than that of the nucleus. The cell is more deformable while the nucleus is more capable of resisting external shear flow. The cell and the nucleus are not able to deform infinitely with the increase of Reynolds number and the deformation index reaches a maximum. We conclude that the nucleus plays a particular role in the mechanical properties of the adherent cell.

  Info
Periodical
Key Engineering Materials (Volumes 330-332)
Main Theme
Edited by
Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu
Pages
1169-1172
DOI
10.4028/www.scientific.net/KEM.330-332.1169
Citation
X. H. Liu, C. Yu, M. J. Zou, H. M. Yin, "Mechanical Properties of Living Adherent Cells: Interaction of Cell and Shear Flow", Key Engineering Materials, Vols. 330-332, pp. 1169-1172, 2007
Online since
February 2007
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Price
$32.00
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