Paper Title:
Repair of Articular Cartilage Defect with Cell-Loaded Nano-HA/PLGA Composites
  Abstract

A novel porous composite scaffold of nano-HA/poly (lactic-co-glycolic) (PLGA) was fabricated by solvent casting/particulate leaching method. Chondrocytes were isolated from the knee articular joints of a rabbit, and then seeded in the scaffolds. The cell-loaded scaffolds were cultured in vitro for 5 days before implantation. Full-thickness articular cartilage defects were created in rabbits, and filled with and without the cell-loaded nano-HA/PLGA scaffolds. The implants were harvested after in vivo incubation of 2 and 5 weeks. Cartilaginous tissues were observed at defects repaired with the cell-loaded scaffolds, while only fibrous tissues were found for the control groups. The repaired tissues were evaluated histologically by hematoxylin and eosin staining. Results revealed that nano-HA/PLGA composite scaffolds facilitated adheration of cells in vitro, and the nano-HA particles could prevented the scaffolds from collapsing and promoted the formation of cartilaginous tissue in vivo.

  Info
Periodical
Key Engineering Materials (Volumes 330-332)
Main Theme
Edited by
Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu
Pages
1185-1188
DOI
10.4028/www.scientific.net/KEM.330-332.1185
Citation
H. Lu, S.M. Zhang, L. Cheng, P.P. Chen, W. Zhou, J. Liu, J.X. Zhou, "Repair of Articular Cartilage Defect with Cell-Loaded Nano-HA/PLGA Composites", Key Engineering Materials, Vols. 330-332, pp. 1185-1188, 2007
Online since
February 2007
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Jae Ho Jeong, S.K. Park, D.J. Lee, Y.M. Moon, D.C. Lee, Hong In Shin, Suk Young Kim
1123
Authors: Tetsuya Tateishi, Guo Ping Chen
Abstract:A new method for the preparation of biodegradable porous scaffolds has been developed by using preprepared ice particulates as porogen...
59
Authors: Guo Ping Chen, M. Tanaka, Tetsuya Tateishi
Abstract:Three-dimensional biodegradable porous scaffolds play an important role in tissue engineering as temporary templates for transplanted cells...
136
Authors: Bing Hui Li, Yong Yu, Dan Xu
Chapter 1: Bio-, Chemical, Food Materials, Material Engineering and Technology
Abstract:The development of tissue engineering techniques for cartilage repair and regeneration provided a new way, according to their own...
68
Authors: Ching Wen Hsu, Ping Liu, Song Song Zhu, Feng Deng, Bi Zhang
Chapter 5: Biomaterials and Healthcare
Abstract:Here we reported a combined technique for articular cartilage repair, consisting of bone arrow mesenchymal stem cells (BMMSCs) and poly...
345