Preparation of Poly(L-lactic Acid) Hybrid Membrane with Silicon-Ion-Releasing Ability

A novel poly(lactic acid) (PLA)/calcium carbonates hybrid membrane containing siloxane was prepared using aminopropyltriethoxysilane (APTES) for biodegradable bone guided regeneration. The PLLA in the membrane was an amorphous phase. By heating the membrane at 100 °C for 1 h, the PLLA in the membrane crystallized. Numerous pores of 0.5-1 ,m in diameter were newly formed at the surface. After soaking the membranes before and after heat-treatment in simulated body fluid, the amount of silicon species in SBF released from the membrane after heat-treatment was higher than that before heat-treatment. A test of osteoblast-like cellular proliferation on the membrane showed the membrane after heat-treatment has much higher cell-proliferation ability than that before heat-treatment.