The objectives of this study are to investigate the influence of class III orthopedic forces generated by repelling rare earth magnets of class III magnetic orthopedic appliance (MOA-III) on the zygmaticomaxillary suture of Rhesus monkeys. Six male Rhesus monkeys in the stage of mixed dentition were used in this study. Fluorescent dyes were injected intravenously in each animal before and during the experimental period. Distinct changes from physiologic growth remodeling were observed in some sutures but not in the control groups. No inflammation was noted in both experimental and control monkeys. The results show that MOA-III is a small intraoral appliance to treat class III malocclusion, and the 300gm per side heavy orthopedic forces are safe and effective for Rhesus monkey.