In Vitro and In Vivo Bactericidal Effect of Sol-Gel/Antibiotic Thin Films on Fixation Devices
| Periodical | Key Engineering Materials (Volumes 330 - 332) |
|---|---|
| Main Theme | Bioceramics 19 |
| Edited by | Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu |
| Pages | 1323-1326 |
| DOI | 10.4028/www.scientific.net/KEM.330-332.1323 |
| Citation | Shula Radin et al., 2007, Key Engineering Materials, 330-332, 1323 |
| Online since | February, 2007 |
| Authors | Shula Radin, V. Antoci, N. Hickok, Christopher S. Adams, Javad Parvizi, I.M. Shapiro, Paul Ducheyne |
| Keywords | Antibiotics, Coating, In Vitro, In Vivo, Sol-Gel (SG) |
| Price | US$ 28,- |
Beneficial properties of room temperature processed silica sol-gels as resorbable and biocompatible materials for the controlled release of drugs and macromolecules have been described before. Recently, it was shown that a thin sol-gel film can be used for the controlled delivery of antibiotics such as vancomycin. It was also demonstrated that the release and degradation properties of the sol-gel films can be tailored via processing parameters. In this work, we evaluated the in vitro and in vivo bactericidal effects of vancomycin-containing thin sol-gel films applied on Ti-alloy intramedullary nails. Both the in vitro and the in vivo results demonstrate a pronounced bactericidal effect of the sol-gel/antibiotic films. This study suggests that thin antibiotic-containing sol-gel film holds great promise for the prevention and treatment of bone infections.
