Paper Title:
In Vitro and In Vivo Bactericidal Effect of Sol-Gel/Antibiotic Thin Films on Fixation Devices
  Abstract

Beneficial properties of room temperature processed silica sol-gels as resorbable and biocompatible materials for the controlled release of drugs and macromolecules have been described before. Recently, it was shown that a thin sol-gel film can be used for the controlled delivery of antibiotics such as vancomycin. It was also demonstrated that the release and degradation properties of the sol-gel films can be tailored via processing parameters. In this work, we evaluated the in vitro and in vivo bactericidal effects of vancomycin-containing thin sol-gel films applied on Ti-alloy intramedullary nails. Both the in vitro and the in vivo results demonstrate a pronounced bactericidal effect of the sol-gel/antibiotic films. This study suggests that thin antibiotic-containing sol-gel film holds great promise for the prevention and treatment of bone infections.

  Info
Periodical
Key Engineering Materials (Volumes 330-332)
Main Theme
Edited by
Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu
Pages
1323-1326
DOI
10.4028/www.scientific.net/KEM.330-332.1323
Citation
S. Radin, V. Antoci, N. Hickok, C. S. Adams, J. Parvizi, I.M. Shapiro, P. Ducheyne, "In Vitro and In Vivo Bactericidal Effect of Sol-Gel/Antibiotic Thin Films on Fixation Devices", Key Engineering Materials, Vols. 330-332, pp. 1323-1326, 2007
Online since
February 2007
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Price
$32.00
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