Paper Title:
Development of Biocompatible Glues for Minimum Invasive Therapy
  Abstract

A biocompatible glue consisting of human serum albumin (HSA) and citric acid derivative (CAD), named CAD-A glue was developed. CAD was successfully synthesized by the reaction between citric acid and N-hydroxysuccinimide in the presence of 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide hydrochloride. When the CAD-A glue was applied to the collagenbased casings, it took 7 min to obtain half of maximum bonding strength (760 g/cm2). The bonding strength of this glue to collagen-based casings increased with increasing of HSA concentration.The bonding strength of CAD-A glue increased with increasing CAD concentration up to 200 mM, and then decreased with increasing CAD concentration under the fixed HSA concentration (50 w/w%). The CAD-A glue showed excellent wound closure ability rather than fibrin glue when applied to the mouse skin. These results suggested that this developed glue had both tissue compatibility and bonding strength for use in clinical field.

  Info
Periodical
Key Engineering Materials (Volumes 330-332)
Main Theme
Edited by
Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu
Pages
1339-1342
DOI
10.4028/www.scientific.net/KEM.330-332.1339
Citation
T. Taguchi, H. Saito, M. Iwasashi, M. Sakane, S. Kakinoki, N. Ochiai, T. Tateishi, "Development of Biocompatible Glues for Minimum Invasive Therapy", Key Engineering Materials, Vols. 330-332, pp. 1339-1342, 2007
Online since
February 2007
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$32.00
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