Paper Title:
Novel Local Treatment with Paclitaxel-Loaded Hydroxyapatite-Alginate Gels for Spinal Bone Metastases
  Abstract

The extent of osseous involvement, particularly spinal cord compression, is directly correlated with patient survival. To treat metastatic spine cancer, we have developed novel paclitaxel-loaded hydroxyapatite-alginate gels. In this study, an intraosseous spinal cancer model in rats was used to investigate the efficacy of local treatment. Ten rats were randomized into two groups, a local treatment group and a control group. Disease-free time and survival rate in the local treatment group were significantly longer in this model. (p<0.05)

  Info
Periodical
Key Engineering Materials (Volumes 330-332)
Main Theme
Edited by
Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu
Pages
1343-1346
DOI
10.4028/www.scientific.net/KEM.330-332.1343
Citation
T. Abe, M. Sakane, T. Ikoma, T. Tonegawa, T. Yoshioka, M. Tanaka, N. Ochiai, "Novel Local Treatment with Paclitaxel-Loaded Hydroxyapatite-Alginate Gels for Spinal Bone Metastases", Key Engineering Materials, Vols. 330-332, pp. 1343-1346, 2007
Online since
February 2007
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Price
$32.00
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