Paper Title:
Biocompatibility of Nano-TiO2/HA Bioceramic Coating for Nerve Regeneration around Dental Implants
  Abstract

Sensory perception thresholds of implants were much higher than those of natural teeth. The purpose of this study was to evaluate the biocompatibility of TiO2/HA-biocoated dental implants for nerve regeneration using cultured Schwann cells. The nano-TiO2/HA composite bioceramic coating was developed on the surfaces of commercially pure titanium discs by sol-gel route, and characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM). Using smooth titanium discs as a control, Schwann cell responses to the coating were evaluated by SEM, MTT assay, total protein content and leakage of cytosolic lactate dehydrogenase (LDH) activity. In addition, the amount of brain-derived neurotrophic factor (BDNF) secreted by Schwann cells was measured by Enzyme-Linked Immunosorbent Assay (ELISA). It was observed that the coating had fine crystallites and homogeneous micropores in the diameter of 5-10 um. The cell morphology, proliferation and function were unaffected. The results indicate that the TiO2/HA bioceramic coating developed on the surface of pure titanium by sol-gel route had good biocompatibility with Schwann cells for nerve regeneration around dental implants.

  Info
Periodical
Key Engineering Materials (Volumes 330-332)
Main Theme
Edited by
Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu
Pages
1393-1396
DOI
10.4028/www.scientific.net/KEM.330-332.1393
Citation
Q. Yuan, G. He, Z. Tan, P. Gong, X. Y. Li, Z. Q. Chen, Y. Ban, H. Tang, F. F. Wang, Y. Man, N. Wei, Z.L. Zhu, "Biocompatibility of Nano-TiO2/HA Bioceramic Coating for Nerve Regeneration around Dental Implants", Key Engineering Materials, Vols. 330-332, pp. 1393-1396, 2007
Online since
February 2007
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Price
$32.00
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