Paper Title:
Influence of Different Hydroxyapatite Particles on the Behavior of Highly Malignant Melanoma Cells
  Abstract

The aim of this study is to reveal the response of highly malignant tumor cell to different hydroxyapatite particles. Human’s highly malignant melanoma (MM) cell line A875 is exposed to two kinds of short-rod hydroxyapatite particles. After incubated with hydroxyapatite particles at different time points, the effects of MM cell morphology, proliferation and invasion are evaluated by SEM, MTT, and MMP2 protein immunohistochemistry respectively. SEM figures show that superficial sentus of MM cells reduce; more secretion is found; and smaller HA particles have more obvious effect. At the same time, no statistic difference can be found in MTT assay and MMP2 expression measurement. This study also provides useful information about biosecurity of hydroxyapatite ceramic in transplantation after highly malignant tumor excision.

  Info
Periodical
Key Engineering Materials (Volumes 330-332)
Main Theme
Edited by
Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu
Pages
279-282
DOI
10.4028/www.scientific.net/KEM.330-332.279
Citation
B. Guo, B. Li, X. L. Wang, M.X. Zhang, N.H. Yan, X. D. Zhang, "Influence of Different Hydroxyapatite Particles on the Behavior of Highly Malignant Melanoma Cells", Key Engineering Materials, Vols. 330-332, pp. 279-282, 2007
Online since
February 2007
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Bao Qiang Li, De Chang Jia, Yu Zhou, Qiao Ling Hu, Wei Cai
Abstract:Magnetic hydroxyapatite/chitosan nanocomposites were prepared via in situ hybridization strategy in the ambient condition. Magnetic...
357
Authors: Qi Feng Yu, Zhen Sheng Li, Bang Cheng Yang, Y. Huang, L. Gan, Yang Qu, Xing Dong Zhang
Abstract:Nano-titania ceramics is a potential biomaterial for orthopaedic application. In our previous studies, a bioactive nano-titania ceramics was...
565
Authors: C. Isikli, N. Hasirci
Abstract:Addition of hydroxyapatite (HAp) into polymeric matrices and use them as supporting material for tissue engineering has gained attraction...
337
Authors: David Marchat, Guénaëlle Bouët, Aline Lueckgen, Maria Zymelka, Luc Malaval, Stéphanie Szenknect, Nicolas Dacheux, Didier Bernache-Assollant, Jérôme Chevalier
VI. Cell Studies and Cell-Material Interactions
Abstract:Studies about silicon-substituted hydroxyapatites exhibit several shortcomings that leave unanswered questions regarding the properties and...
351
Authors: Qing Zong Si, Xiao Li An, Yang Li, Bin Liu, Jin Qing Wang
Chapter 1: Materials Science Engineering and Materials Processing Technology in Manufacturing
Abstract:In order to prepare bioactive hydroxyapatite (Ca10 (PO4)6(OH) 2, HA) coating with ideal biocompatibility, the surface of titanium alloy was...
61