Paper Title:
A Novel Approach to Prepare Nano-Hydroxyapatite / Silk Fibroin Composite to Increase Nucleation Sites
  Abstract

A composite of needle-like nano-Hydroxyapatite / silk fibroin (n-HA/SF) with strong interfacial bonding was successfully prepared from calcium chloride (CaCl2) and diammonium phosphate ((NH4)2HPO4) as starting materials of HA in the presence of SF powders dissolved in a ternary solvent system of CaCl2-C2H5OH-H2O (1:2:8 in molar ration) at 80 °C for 30 min prior to preparation of n-HA/SF composite. The n-HA crystals in the composite were poorly crystallized and uniformly distributed in the composite with a crystal size of 4~6 nm in diameter and 20~40 nm in length, which was smaller than that of pure nano-HA. Molecular interaction and strong chemical bonds were formed between n-HA and SF in the composite, which were revealed by Fourier transform infrared spectrometric analysis (FTIR). The synthetic n-HA/SF composite had a good homogeneity and preferential orientation along c-axis and would have a great potential for bone tissue engineering.

  Info
Periodical
Key Engineering Materials (Volumes 330-332)
Main Theme
Edited by
Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu
Pages
341-344
DOI
10.4028/www.scientific.net/KEM.330-332.341
Citation
J. Wang, M. Q. Li, X. C. Meng, G. W. Wen, "A Novel Approach to Prepare Nano-Hydroxyapatite / Silk Fibroin Composite to Increase Nucleation Sites", Key Engineering Materials, Vols. 330-332, pp. 341-344, 2007
Online since
February 2007
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