Paper Title:
Preparation and Cytocompatibility of Novel Nano-HA/PLA Composite
  Abstract

In order to prepare nano-hydroxyapatite/poly(lactide) (n-HA/PLA) composite with good interfacial interaction, some groups which could bind with Ca ions in HA crystals need to be introduced onto PLA surface. Poly(α-methacrylic acid) (PMAA) was grafted on the PLA surfaces via photooxidization and subsequent UV induced polymerization. Suspension of PMAA-PLA microparticles with an average size as 133.1nm was prepared with solvent evaporation technique. Then utilizing the action of template manipulating of PMAA-PLA microparticles, n-HA/PLA composite were synthesized. Zeta potentials measurement and SEM indicated that there were good interfacial interactions between two phases of n-HA/PLA composite. The results of cell viability confirmed that n-HA/PLA composite possessed good cytocompatibility, so the n-HA/PLA composite scaffold obtained by electrospun technology might be used as bone tissue engineering scaffold.

  Info
Periodical
Key Engineering Materials (Volumes 330-332)
Main Theme
Edited by
Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu
Pages
369-372
DOI
10.4028/www.scientific.net/KEM.330-332.369
Citation
W. Q. Xiao, Y. M. Xiao, X. T. Wen, H. S. Fan, X. D. Zhang, "Preparation and Cytocompatibility of Novel Nano-HA/PLA Composite", Key Engineering Materials, Vols. 330-332, pp. 369-372, 2007
Online since
February 2007
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Price
$32.00
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